pharmacological effects of origanum vulgare l. in the elevated plus-maze and open field tests in the rat

نویسندگان

tajmah mombeini

soroush mazloumi

jamal shams

چکیده

background and objective: the medicinal plant origanum vulgare. subsp. vulgare in the lamiaceae family has been widely used by iranian people for the treatment of respiratory, gastrointestinal and neurologic disorders. the present study was carried out to evaluate possible anxiolytic effects of aqueous extract of o. vulgare leaves and the flowering branches in rats.materials and methods: anxiolytic activity was assessed using the elevated plus-maze test. in addition, the possible sedative effect and muscle relaxant effect were evaluated using open field test and horizontal wire test, respectively. single doses of o. vulgare extract(50, 100 and 200 m/kg) were administered intraperitoneally in male rats. control rats were treated with an equal volume of saline, and the positive control rats with diazepam.results: in the elevated plus-maze, o. vulgare extract(200 mg/kg) increased percent of time spent on open arms(p

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Pharmacological Effects of Origanum Vulgare L. in the Elevated Plus-Maze and Open Field Tests in the Rat

Background and Objective: The medicinal plant Origanum vulgare. subsp. vulgare in the Lamiaceae family has been widely used by Iranian people for the treatment of respiratory, gastrointestinal and neurologic disorders. The present study was carried out to evaluate possible anxiolytic effects of aqueous extract of O. vulgare leaves and the flowering branches in rats.Materials and Methods: Anxiol...

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Pharmacological Effects of Origanum Vulgare L. in the Elevated Plus-Maze and Open Field Tests in the Rat

1. Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran. 2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. School of Medicine, Shahed University, Tehran, Iran. 4. Department of Psychiatry, Shahid Beheshti University of Medical Sciences; Tehran, Iran. 5. Behavioral Research Center, Shahid Beheshti University of Medical Sc...

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عنوان ژورنال:
journal of basic and clinical pathophysiology

ناشر: shahed university

ISSN 2322-1895

دوره 3

شماره 2 2015

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